This system facilitates targeted, minimally invasive neuroimaging with an axial resolution of about 2.4 ฮผm and a transverse resolution of around 4.5 ฮผm in the deep brain in vivo. The skullbot enables precise deployment of the neuroendoscope with a targeting accuracy of ยฑ1.5 mm transversely and ยฑ0.25 mm longitudinally, confirmed through optical phantom studies. The skullbot can be securely attached to the head, allowing for motion-insensitive stereotactic imaging within the brain.
We validated the system’s capabilities by demonstrating targeted imaging of a tumor in a brain phantom and conducting in vivo micro-resolution volumetric neuroimaging of fine structures within a mouse brain. This advanced device offers in situ disease evaluation at a micro- resolution level and serves as a promising intraoperative imaging tool, complementing existing4 clinical whole-brain imaging modalities such as MRI.
Our findings suggest that the neuroOCT system can significantly advance minimally invasive high-resolution targeted neuroendoscopy, thereby improving patient safety during neurosurgical procedures.
The paper will be available at https://lnkd.in/gFREQFbS
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This is a collabrative work between CUHK ABI Lab (https://lnkd.in/gUuzQqDt) and REN Lab (http://www.labren.org/mm/).
Congrates to authors: Chao Xu+, Zhiwei Fang+, Huxin Gao, Tinghua Zhang, Tao Zhang, Peng Liu, Hongliang Ren*, and Wu ‘Scott’ YUAN*
