{"id":1700,"date":"2015-05-24T01:03:32","date_gmt":"2015-05-24T01:03:32","guid":{"rendered":"http:\/\/bioeng.nus.edu.sg\/mm\/?p=1700"},"modified":"2015-05-24T01:03:32","modified_gmt":"2015-05-24T01:03:32","slug":"preliminary-design-towards-a-magnetic-actuated-drug-delivery-system-2","status":"publish","type":"post","link":"http:\/\/www.labren.org\/mm\/projects\/fyp\/preliminary-design-towards-a-magnetic-actuated-drug-delivery-system-2\/","title":{"rendered":"FYP: Towards Magnetic Actuated Drug Delivery"},"content":{"rendered":"<h2>Project Goals<\/h2>\n<p>The objectives of this project are to design and evaluate the performance of an electromagnetic actuated (EMA) drug delivery system and explore the related issues.<\/p>\n<h2>Approaches<\/h2>\n<p>The EMA system consists of magneto-responsive microcapsules as drug carriers, a coil system with controlled currents flowing through, as well as a tracking algorithm for close loop feedback control.<br \/>\nThe magneto-responsive and thermal sensitive microcapsules are prepared through an encapsulator. The properties can be further utilized for controlled drug release. The encapsulated microbubbles are prepared based on a gas foaming technique for enhancing the ultrasound imaging contrast.<br \/>\nThe coil system consists of 2 Helmoholz coil pairs and 2 Maxwell coil pairs are fabricated with printed aluminum skeleton and copper wires. A current control system including 3 DC motor governors and a USB to RS485 converter are added to realize programmable current control. Hence, the magnetic fields generated by the coils are controlled by the signals sent by the computer. Figure 1 shows the principle of actuation over the microcapsules.<br \/>\n<a href=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/16.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-1704 alignnone\" src=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/16-300x203.jpg\" alt=\"1\" width=\"300\" height=\"203\" srcset=\"http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/16-300x203.jpg 300w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/16-150x102.jpg 150w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/16.jpg 503w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\nFig. 1: Principle of Magnetic Actuation over the Microcapsules<\/p>\n<h2>Results<\/h2>\n<p>Figure 2 shows the preliminary set up for actuation over microparticles within the region of interest.<br \/>\n<a href=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/22.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-1714 alignnone\" src=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/22-300x164.jpg\" alt=\"2\" width=\"300\" height=\"164\" srcset=\"http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/22-300x164.jpg 300w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/22-768x420.jpg 768w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/22-640x350.jpg 640w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/22-150x82.jpg 150w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/22.jpg 957w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\nFig. 2 Setup for Microparticles Actuation<br \/>\nMicrocapsules with evenly distributed magnetic stripes have been fabricated. The stripes make the spherical microcapsules asymmetric so that their locomotion control is directed. Alignment and movement of the microcapsules are observed in the EMA system under DC output, while rotation is observed under sinusoidal output current.<br \/>\n<a href=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/31.jpg\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1707 alignnone\" src=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/4-300x225.jpg\" alt=\"4\" width=\"316\" height=\"237\" srcset=\"http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/4-300x225.jpg 300w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/4-466x350.jpg 466w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/4-150x113.jpg 150w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/4.jpg 602w\" sizes=\"auto, (max-width: 316px) 100vw, 316px\" \/><\/a><br \/>\nFig. 3 Microcapsules with magnetic CI strips. Scale bar: 200\u03bcm.<br \/>\n<a href=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/51.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1709\" src=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/51.jpg\" alt=\"5\" width=\"205\" height=\"206\" srcset=\"http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/51.jpg 276w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/51-150x150.jpg 150w\" sizes=\"auto, (max-width: 205px) 100vw, 205px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1710\" src=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/61.jpg\" alt=\"6\" width=\"211\" height=\"205\" \/><\/a><br \/>\nFig.4 Magnetic actuation with (A)small cylindrical magnet and (B)magnetic microcapsules<\/p>\n<h2>People Involved<\/h2>\n<p>Staff: Shen Shen, Song Shuang and Zhu Jingling<br \/>\nPIs: Ren Hongliang and Li Jun<\/p>\n<h2>Experiment Videos<\/h2>\n<h2>Presentations and Publications<\/h2>\n<p>1\uff0eShen Shen, Shuang Song, Jingling Zhu, Max Q-H Meng, Jun Li and Hongliang Ren, Preliminary Design towards a Magnetic Actuated Drug Delivery System, 7th IEEE International Conference on Cybernetics and Intelligent Systems and the 7th IEEE International Conference on Robotics, Automation and Mechatronics, 2015.<\/p>\n<h2>Poster in BME Showcase 2015<\/h2>\n<p><a href=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/71.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1711 size-large alignnone\" src=\"http:\/\/bioeng.nus.edu.sg\/mm\/wp-content\/uploads\/2015\/07\/71-724x1024.jpg\" alt=\"7\" width=\"724\" height=\"1024\" srcset=\"http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/71-724x1024.jpg 724w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/71-212x300.jpg 212w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/71-768x1087.jpg 768w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/71-247x350.jpg 247w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/71-106x150.jpg 106w, http:\/\/www.labren.org\/mm\/wp-content\/uploads\/2015\/07\/71.jpg 1380w\" sizes=\"auto, (max-width: 724px) 100vw, 724px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Project Goals The objectives of this project are to design and evaluate the performance of an electromagnetic actuated (EMA) drug delivery system and explore the related issues. Approaches The EMA system consists of magneto-responsive microcapsules as drug carriers, a coil system with controlled currents flowing through, as well as a\u2026 <a class=\"continue-reading-link\" href=\"http:\/\/www.labren.org\/mm\/projects\/fyp\/preliminary-design-towards-a-magnetic-actuated-drug-delivery-system-2\/\">Continue reading<\/a><\/p>\n","protected":false},"author":1,"featured_media":1706,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[38],"tags":[62,77,95],"class_list":["post-1700","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fyp","tag-ema","tag-magnetic-robotics","tag-surgical-robotics"],"_links":{"self":[{"href":"http:\/\/www.labren.org\/mm\/wp-json\/wp\/v2\/posts\/1700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.labren.org\/mm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.labren.org\/mm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.labren.org\/mm\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.labren.org\/mm\/wp-json\/wp\/v2\/comments?post=1700"}],"version-history":[{"count":0,"href":"http:\/\/www.labren.org\/mm\/wp-json\/wp\/v2\/posts\/1700\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.labren.org\/mm\/wp-json\/wp\/v2\/media\/1706"}],"wp:attachment":[{"href":"http:\/\/www.labren.org\/mm\/wp-json\/wp\/v2\/media?parent=1700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.labren.org\/mm\/wp-json\/wp\/v2\/categories?post=1700"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.labren.org\/mm\/wp-json\/wp\/v2\/tags?post=1700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}